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Smiles: CN1CCN(CC1)C1=CC=C(C=C1NC(=O)C1=CNC(=O)C=C1C(F)(F)F)C1=CC(CN2CCOCC2)=CC=C1
VE-821 izatriptan (benzoate) Smiles: CN1CCN(CC1)C1=CC=C(C=C1NC(=O)C1=CNC(=O)C=C1C(F)(F)F)C1=CC(CN2CCOCC2)=CC=C1VE 821 is the first highly selective and potent ATR inhibitor. VE 821 inhibited radiation and gemcitabine induced phosphorylation of Chk1, confirming inhibition of ATR signaling. Consistently, VE 821 significantly enhanced the sensitivity of PSN 1, MiaPaCa 2 and primary PancM pancreatic cancer cells to radiation and gemcitabine under both normoxic and hypoxic conditions. ATR inhibition by VE 821 led to inhibition of radiation induced G 2 M arrest in
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